I've been considering it for a little while now, but I'm going for it. As of this moment I'm using WebKit as my default browser. We'll see how things go!
UPDATE: This didn't last long actually. I would have really loved to just go for it, however I use Safari as my RSS reader, and there's no user accessible way to set WebKit as the RSS reader. I'll look more into it later. Oh well, back to Safari for now.